摘要
The worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 4.5 million deaths.Although coronaviruses have a proofreading mechanism to maintain the stability of their long genomic RNAs,mutations emerge continuously,and new variants conferring advantages rapidly become the dominant lineages[1].Strategies to fight the COVID-19 pandemic using either vaccines or nonpharmaceutical interventions have specifically been threatened by the emergence of SARS-CoV-2 variants of concern(VOCs)[2].
基金
This work was supported by the National Special Research Program of China for Important Infectious Diseases(2017ZX10202102 and 2018ZX10302103)
the Special 2019-nCoV Project of the National Key Research and Development Program of China(2020YFC0841400)
the Emergency Key Program of Guangzhou Laboratory(EKPG21-24)
the Special 2019-nCoV Program of the Natural Science Foundation of China(NSFC)(82041002)
the Special Research and Development Program of Guangzhou(202008070010)
the Important Key Program of NSFC(81730060)to HZ
This work was also supported by the Zhongnanshan Medical Foundation of Guangdong Province(ZNSA-2021004)
the Emergency Key Program of Guangzhou Laboratory(EKPG21-29)to XT
This work was supported by the National Natural Science Foundation of China(32100743,82171825)to XH.This work was also supported by the National Natural Science Foundation of China(81971918)
the Shenzhen Science and Technology Program(Grant Nos.JSGG20200225150431472 and JCYJ20200109142601702)
the Pearl River S&T Nova Program of Guangzhou(201806010118)and the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(2021qntd43)to TP
This work was supported by National Natural Science Foundation of China(32100743,82171825)to X.H.
