体重指数和血小板分布宽度在成人急性髓系白血病M2型患者预后中的意义

Significance of Body Mass Index and Platelet Distribution Width in the Prognosis of Adult Patients with Acute Myeloid Leukemia M2.

目的探讨体重指数(BMI)、血小板分布宽度(PDW)对成人急性髓系白血病M2型(AML-M2)患者预后的影响。方法回顾性分析2012年1月~2019年6月徐州医科大学附属医院收治的254例AML-M2型患者的临床资料。根据BMI将患者分为正常体重组(BMI<24.0kg/m^(2),体重过轻和正常)、超重组(24.0kg/m^(2)≤BMI<28.0kg/m^(2))和肥胖组(BMI≥28.0kg/m^(2)),根据PDW分为低PDW组和高PDW组,比较各组患者临床指标的差异,并采用Kaplan-Meier方法和COX回归模型评价BMI和PDW的预后评估价值。结果多因素生存分析显示,24.0kg/m^(2)≤BMI<28.0kg/m^(2)(RFS:P=0.022,OS:P=0.019)、BMI≥28.0kg/m^(2)(RFS:P=0.006,OS:P=0.005)、PDW≥13.10(OS:P=0.024)是影响患者预后的独立危险因素。结论较高BMI和PDW的成人AML-M2型患者的预后差,BMI和PDW可能为成人AML-M2型患者潜在的预后标志物。

Objective To explore the influence of body mass index(BMI)and platelet distribution width(PDW)on the prognosis of adult patients with acute myeloid leukemia M2(AML-M2).Methods The clinical data of 254 AML-M2 patients admitted to the Affiliated Hospital of Xuzhou Medical University from January 2012 to June 2019 were retrospectively analyzed.According to BMI,patients were divided into normal weight group(BMI<24.0kg/m^(2),underweight and normal),overweight group(24.0kg/m^(2)≤BMI<28.0kg/m^(2)),obese group(BMI≥28.0kg/m^(2)),According to PDW,it was divided into low PDW group and high PDW group.The differences in clinical indicators of patients in each group were compared,and Kaplan-Meier method and COX regression model were used to evaluate the prognostic evaluation value of BMI and PDW.Results Multivariate survival analysis showed that 24.0kg/m^(2)≤BMI<28.0kg/m^(2)(RFS:P=0.022,OS:P=0.019),BMI≥28.0kg/m^(2)(RFS:P=0.006,OS:P=0.005),PDW≥13.10(OS:P=0.024)was an independent risk factor affecting the prognosis of patients.Conclusion Adults AML-M2 patients with higher BMI and PDW have a poor prognosis.BMI and PDW may be potential prognostic markers for adult AML-M2 patients.