干细胞治疗糖尿病足创面的研究进展

Research advances on stem cell therapy for diabetic foot wounds

糖尿病足创面修复是临床棘手问题,由于机体局部组织损毁且再生障碍,通过血管、神经营养修复创面的途径受损,多种细胞因子紊乱等多因素影响,传统治疗方法往往难以取得良好治疗效果。干细胞是一类具有多向分化潜能的细胞,且具有免疫调节、旁分泌等功能,有助于全方位修复创面,目前在糖尿病足创面中极具应用前景。但由于干细胞治疗相关参数仍然处于探索阶段,尚无标准化数据。本文综述了近6年来干细胞在糖尿病足创面治疗研究中的应用,重点对研究中的干细胞类型和来源,供体年龄、性别对干细胞的影响,给药方式,移植存活率,安全性等内容进行总结和分析,为干细胞进一步应用于临床上糖尿病足创面的治疗提供参考。

Diabetic foot wound repair is a challenging issue in clinical practice.Due to the influence of multiple factors including the damage and regeneration failure of local tissue,the impaired pathways of wound repairing through blood vessels and nerve nutrition,and disorders of a variety of cellular factors,traditional treatment methods are often difficult to achieve good therapeutic effects.Stem cells are a type of cells with potentials of multidirectional differentiation,which also possess functions such as regulating immunity and paracrine to facilitate the comprehensive wound repair,so they have promising application prospect at present for the treatment of diabetic foot wounds.Because the relevant parameters of stem cell treatment are in the exploratory phase,there were no standardized data.This paper reviews the application of stem cells in the research of diabetic foot wound treatment over the past 6 years,analyzing and summarizing the contents in focused aspects including the types and sources of stem cells,effects of donor age and gender on stem cells,mode of administration,transplantation survival rate and safety,which may provide a reference for further application of stem cells in the clinical treatment of diabetic foot wound.