摘要
Antigen-presenting cells(APCs)may be resistant to SARS-CoV-2 infection but still contribute to viral pathogenesis.Lectins such as sialic acid-binding Ig-like lectin 1(Siglec-1/CD169)mediate the attachment of viruses to APCs.Here,we show that APCs effectively capture SARS-CoV-2 within compartments via recognition of Siglec-1.This receptor interacts with sialylated gangliosides on membranes of SARS-CoV-2 variants.
基金
The authors also acknowledge the crowdfunding initiative#Yomecorono(https://www.yomecorono.com).N.I.-U.is supported by the grant PID2020-117145RB-I00 from the Spanish Ministry of Science and Innovation
J.M.-P.is supported by the grant PID2019-109870RB-I00 from the Spanish Ministry of Science and Innovation and in part also by Grifols.The C.R.laboratory is funded by RTI2018-094445-B100(MCIU/AEI/FEDER,UE)
The NHP study was primarily supported by a YNPRC Coronavirus Pilot Research Project Program grant to M.Pa.under award P51 OD11132,Emergent Venture Fast grant program to M.Pa.under awards#2206 and#2144,and William and Lula Pitts Foundation(to M.Pa.)
X.M.-T.is supported by the Spanish Ministry of Science and Innovation and the European Regional Development Fund under agreement BES-2017-082900.The funders had no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.
