Sodium butyrate affects the proliferation and apoptosis of steatosis HepG2 cells via G proteincoupled receptor 43/109a-phosphorylated protein kinase B-mammalian target of rapamycin signaling pathway

Objective To investigate the effects and mechanism of gut metabolite sodium butyrate on the proliferation and apoptosis of steatosis HepG2 cellsin vitro.Methods The in vitrosteatosis hepatocyte model was established with human liver cell line HepG2 and free fatty acid(FFA;the concentration ratio of oleic acid to palmitic acid was 2∶1).