Transcription factor EB related autophagy in the treatment of multiple myeloma and its mechanism

Objective To clarify the effects of bortezomib combined with or without siramesine on the proliferation of multiple myeloma cell lines,the expression changes of transcription factor EBC(TFEB)nuclear translocation and the level of autophagy,and to provide basis for further exploring the regulation mechanism of transcription factor TFEB on autophagy.