长链非编码RNA-微小RNA-mRNA轴在脓毒症中的调控作用研究进展

Potential regulatory role of long non-coding RNA-microRNA-mRNA axis in sepsis

脓毒症是一种威胁生命的多器官功能障碍性疾病,病死率高,已成为影响重症监护病房(ICU)患者死亡的主要原因之一。长链非编码RNA(lncRNA)和微小RNA(miRNA)都参与了脓毒症的病理生理学过程,并能调控炎症反应,均可作为脓毒症的重要诊断指标和治疗靶点。LncRNA、miRNA和mRNA之间相互作用,在脓毒症和多器官功能障碍中起着重要作用。本文就lncRNA、miRNA和mRNA的调控关系,以及lncRNA-miRNA-mRNA轴在脓毒症炎症免疫反应和多器官功能障碍疾病中的调控作用进行综述,以期为脓毒症及器官功能障碍的治疗提供新靶点和新策略。

Sepsis is a life-threatening multiple organ dysfunction disease with high mortality and has become leading causes of death affecting intensive care unit(ICU)patients.Both long non-coding RNA(lncRNA)and microRNA(miRNA)are involved in the pathophysiological process of sepsis and can regulate the inflammatory response,both of which could be used as important diagnostic indicators and therapeutic targets of sepsis.The interaction among lncRNA,miRNA and messenger RNA(mRNA)plays an important role in sepsis and multiple organ dysfunction.This paper reviewed the regulatory relationship of lncRNA,miRNA and mRNA,as well as the regulatory role of lncRNA-miRNA-mRNA axis in inflammatory immune response and multiple organ dysfunction syndrome in sepsis,to provide new targets and strategies for the treatment of sepsis and organ dysfunction.