Regional and temporal patterns of influenza: Application of functional data analysis

Background:The accurate estimation of temporal patterns of influenza may help in utilizing hospital resources and guiding influenza surveillance.This paper proposes functional data analysis(FDA)to improve the prediction of temporal patterns of influenza.Methods:We illustrate FDA methods using the weekly Influenza-like Illness(ILI)activity level data from the U.S.We propose to use the Fourier basis function for transforming discrete weekly data to the smoothed functional ILI activities.Functional analysis of variance(FANOVA)is used to examine the regional differences in temporal patterns and the impact of state's political orientation.Results:The ILI activity has a very distinct peak at the beginning and end of the year.There are significant differences in average level of ILI activities among geographic regions.However,the temporal patterns in terms of the peak and flat time are quite consistent across regions.The geographic and temporal patterns of ILI activities also depend on the political make-up of states.The states affiliated with Republicans had higher ILI activities than those affiliated with Democrats across the whole year.The influence of political party affiliation on temporal pattern is quite different among geographic regions.Conclusions:Functional data analysis can help us to reveal the temporal variability in average ILI levels,rate of change in ILI levels,and the effect of geographical regions.Consideration should be given to wider application of FDA to generate more accurate estimates in public health and biomedical research.