王氏养生法对非酒精性脂肪性肝病患者肝功能及体脂分布的影响

Effect of Wang′s regimen exercise prescription on liver function and body fat distribution in non-alcoholic fatty liver disease patients

目的:对非酒精性脂肪性肝病(NAFLD)患者进行王氏养生法运动处方干预24周,研究本功法对NAFLD患者肝功能、体脂分布的影响。方法:将110例NAFLD患者随机分为对照组、普通减重组、养生组。对照组患者不参加有氧运动,普通减重组患者每天坚持中等量有氧运动30 min,每周5次,或者每天高强度有氧运动20 min,每周3次;养生组患者至少每周1~2次王氏养生运动。结果:干预结束后养生组患者BMI、WC、WHR、ALT、AST、GGT、CAP、LSM水平明显改善,与对照组比较,差异有统计学意义(均P<0.01);养生组与普通减重组患者比较,养生组患者BMI、ALT、CAP和LSM的改善优于普通减重组(BMI、LSM,均P<0.05;ALT、CAP,均P<0.01)。结论:王氏养生法对NAFLD患者具有较好地减重、降酶效果,对降低肝内脂肪含量、减轻肝脏炎性反应、改善肝脏纤维化具有显著的作用。

Objective:To explore the effect of Wang’s regimen exercise prescription for 24 weeks in patients with non-alcoholic fatty liver disease(NAFLD),on liver function and body fat distribution in patients with NAFLD.Methods:According to the different intervention measures and the frequency of practicing Wang’s regimen,110 NAFLD populations were randomly divided into control group,normal reduction group,and regimen group.Patients of the control group did not participate in aerobic exercise.Patients of ordinary weight reduction group were insisted on moderate aerobic exercise every day for 30 minutes,five times a week,or high-intensity aerobic exercise every day for 20 minutes,three times a week.In the regimen group,the Wang’s three methods of health exercise were performed on at least once or twice times a week,each lasting 30 minutes,and the heart rate was controlled at 90-100 beats/min.Results:Before and after intervention and compared with the control group,the body fat distribution,biochemical indexes,intrahepatic steatosis and liver stiffness index were significantly improved(BMI、WC、WHR、ALT、AST、GGT、CAP、LSM,all P<0.01).Further comparison of the difference between Wang’s health maintenance method and ordinary weight reduction method,it was showed that the Wang’s health maintenance method group was better than ordinary weight reduction method(BMI、LSM,all P<0.05;ALT、CAP,all P<0.01).Conclusion:The patients who practice Wang’s health regimen showed significant weight loss and enzyme reduction effects,which had a significant effect on reducing liver fat content,reducing liver inflammation,and improving liver fibrosis.