异甘草酸镁对小儿轮状病毒肠炎肝损伤的防护作用研究

Protective effect of magnesium isoglycyrrhizinate on liver injury induced by rotavirus enteritis in children

目的:观察异甘草酸镁对小儿轮状病毒肠炎肝损伤的保护作用。方法:选取2018年3月至2020年7月我院治疗的轮状病毒肠炎伴发肝损伤患儿144例,使用随机数字表法分为对照组和观察组,每组72例。检测每组患儿丙氨酸转氨酶(ALT)、天门氨酸氨基转移酶(AST),酶联免疫吸附试验(ELISA)检测P65、肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)。结果:治疗后观察组患儿的ALT和AST均显著低于对照组(P<0.01)。观察组患儿P65、TNF-α和IL-6均显著低于对照组(P<0.01)。观察组患儿治疗有效率为93.1%(67/72),显著高于对照组的76.4%(55/72)(P<0.05)。观察组患儿不良反应发生率为4.2%(3/72),对照组患儿为2.8%(2/72),两组不良反应无显著性差异(P>0.05)。结论:异甘草酸镁可降低轮状病毒性肠炎患儿炎性反应,发挥对肝损伤的保护作用,临床疗效显著。

Objective:To detect the protective effects of magnesium isoglycyrrhizinate on liver injury induced by rotavirus enteritis in children.Methods:A total of 144 rotavirus enteritis children was enrolled in this study.Patients were divided into:control group(n=72) and observation group(n=72).ALT and AST were detected by enzymatic cycling method.The levels of P65,TNF-α,and IL-6 were detected by ELISA analysis.Results:Before treatment,there was no significant difference between the two groups(P>0.05).After treatment,ALT and AST in the observation group were lower than that in the control group(P<0.01).P65,TNF-α,and IL-6 in the observation group was lower than that in control group(P<0.01).The clinical effect rate in observation was 93.1%(67/72),which was higher than that of 76.4%(55/72) in the control group(P<0.05).The rate of adverse reaction was 4.2%(3/72) in the observation group and 2.8%(2/72) in the control group.There was no significant difference between the two groups(P>0.05).Conclusion:Magnesium Isoglycyrrhizinate inhibited NF-κB pathway and inflammatory reaction to protect against liver injury in rotavirus enteritis children,with significant clinical effect.