醒脑静注射液辅助急诊溶栓抗凝治疗急性脑梗塞的临床效果及对患者死亡率的影响

Clinical effect of Xingnaojing injection assisted emergency thrombolysis and anticoagulation in the treatment of acute cerebral infarction and its influence on mortality of patients

目的 探讨醒脑静注射液辅助急诊溶栓抗凝治疗急性脑梗塞的临床效果及对患者死亡率的影响。方法 选择2014年1月至2020年12月我院收治的88例急性脑梗塞患者,遵循随机原则将其分为研究(1)组和研究(2)组,每组44例。研究(1)组接受急诊溶栓抗凝治疗,研究(2)组接受醒脑静注射液辅助急诊溶栓抗凝治疗。比较两组的治疗效果。结果研究(2)组的临床病情控制总有效率高于研究(1)组,差异具有统计学意义(P<0.05)。治疗前,两组的Hcy、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗2周后,研究(2)组的Hcy、hs-CRP水平低于研究(1)组,差异具有统计学意义(P<0.05)。治疗前,两组的GOS、mRS评分比较,差异无统计学意义(P>0.05);治疗2周后,研究(2)组的GOS评分高于研究(1)组,mRS评分低于研究(1)组,差异具有统计学意义(P<0.05)。研究(2)组的死亡率低于研究(1)组,差异具有统计学意义(P<0.05)。结论 醒脑静注射液辅助急诊溶栓抗凝治疗急性脑梗塞患者的效果显著,可减轻神经功能缺损情况,降低死亡率,值得推荐。

Objective To explore the clinical effect of Xingnaojing injection assisted emergency thrombolysis and anticoagulation in the treatment of acute cerebral infarction and its influence on mortality of patients. Methods A total of88 patients with acute cerebral infarction admitted in our hospital from January 2014 to December 2020 were selected and divided into study group(1) and study group(2) according to the principle of randomization, with 44 cases in each group. The study group(1) received emergency thrombolysis and anticoagulation therapy, the study group(2) received Xingnaojing injection assisted emergency thrombolysis and anticoagulation therapy. The therapeutic effects of the two groups were compared. Results The total effective rate of clinical disease control in the study group(2) was higher than that in the study group(1), and the difference was statistically significant(P <0.05). Before treatment, there were no significant differences in Hcy and hs-CRP levels between the two groups(P>0.05);after 2 weeks of treatment, the levels of Hcy and hs-CRP in the study group(2) were lower than those in the study group(1), and the differences were statistically significant(P<0.05). Before treatment, there were no significant differences in GOS and mRS scores between the two groups(P>0.05);after 2 weeks of treatment, GOS score in the study group(2) was higher than that in the study group(1), m RS score was lower than that in the study group(1), and the differences were statistically significant(P<0.05).The mortality in the study group(2) was lower than that in the study group(1), and the difference was statistically significant(P <0.05). Conclusion Xingnaojing injection assisted emergency thrombolysis and anticoagulation has a significant effect on the treatment of patients with acute cerebral infarction, it can reduce neurological defects and mortality, which is worth recommending.