乳腺癌的分子核医学研究进展

Research progress of molecular nuclear medicine imaging in breast cancer

乳腺癌是一种具有高度异质性、高发病率、高死亡率的癌症。个体化的早期准确诊断和治疗是提高患者生存率的有效手段。分子核医学将分子生物学技术与核医学相结合,在分子、细胞、活体水平对机体生物学行为进行定性和定量研究,是一种高度可重复、安全且无创的影像技术,广泛应用于各种恶性肿瘤的诊断、分期、预后预测和疗效评估。本文主要对分子核医学代谢显像、受体显像、基因显像和免疫PET显像在乳腺癌中的应用进行综述。

Breast cancer is a high incidence and mortality cancer with high heterogeneity.Early accurate diagnosis and individualized treatment are effective means to improve the survival rate of patients.Molecular nuclear medicine imaging combines molecular biology technology with nuclear medicine,qualitative and quantitative studying the biological behavior of cancer in molecules,cells and living levels.It is a highly repeatable,safe and non-invasive imaging,which is widely used in the diagnosis,staging,prognosis prediction and efficacy evaluation of various malignant tumors.This article reviewed the molecular nuclear medicine of breast cancer,including metabolic,receptor,gene and immunoPET imaging.