糖酵解调控肿瘤中髓系来源抑制细胞的研究进展

Research advances of glycolysis in regulating myeloid-derived suppressor cells in tumors

髓系来源的抑制细胞(myeloid-derived suppressor cells,MDSCs)是一种骨髓来源的具有异质性及免疫抑制活性的不成熟细胞,常在如炎症、感染及肿瘤等病理情况下由正常骨髓前体细胞增殖分化形成,在肿瘤免疫方面起到重要的作用。而在肿瘤微环境中,有氧糖酵解是其主要糖代谢方式,糖代谢过程的重编程将增强MDSCs的免疫抑制活性,从而抑制效应T细胞的增殖与功能。现有的研究主要涉及腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK),其作为上游调控因子,通过多条信号通路调控下游基因,实现对MDSCs糖代谢的调控。本文将对糖酵解相关信号通路及其对MDSCs功能的影响进行综述。

Myeloid-derived suppressor cells(MDSCs)are bone marrow-derived immature cells with heterogeneity and immunosuppressive activity.They often originate from common myeloid progenitors in pathological conditions such as inflammation,infection,and tumor,and play an important role in tumor immunity.In tumor microenvironment,glucose metabolism occurs mainly through aerobic glycolysis.Hence,the reprogramming of glucose metabolism will enhance the immunosuppressive activity of MDSCs,inhibiting the proliferation and function of effector T cells.Existing research mainly involves the regulation of glucose metabolism of MDSCs by using AMP-activated protein kinase(AMPK)as the upstream regulator to regulate downstream genes through multiple signal pathways.This study summarizes the glycolysis-related signaling pathways and their effects on the function of MDSCs.