中性粒细胞胞外诱捕网在弥漫性大B细胞淋巴瘤中的研究进展

Research advances on neutrophil extracellular traps in diffuse large B-cell lymphoma

中性粒细胞作为血液循环中的一种静态细胞,在受到微生物侵袭时发挥吞噬及杀菌作用,中性粒细胞激活后形成一种特殊的网状结构-中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)。NETs是一把双刃剑。正常情况下,NETs发挥清除病原微生物的作用,但NETs产生过量时,其则参与多种疾病的发展过程,如自身免疫性疾病、糖尿病、动脉粥样硬化、血管炎等疾病。此外,NETs还与多种恶性肿瘤的增殖、转移、预后等密切相关。本文将从NETs的形成及其对弥漫性大细胞淋巴瘤的影响进行综述。

Neutrophils are static cells in blood circulation that play a phagocytic and bactericidal role when they are invaded by microorganisms.After neutrophils are activated,they form special reticular structures called neutrophil extracellular traps(NETs)that have recently been found to be a double-edged sword.Under normal circumstances,NETs play a role in eliminating pathogenic microorganisms.However,excessive NETs contribute to the development of diseases,such as autoimmune diseases,diabetes,atherosclerosis,and vasculitis.NETs are also closely related to the proliferation,metastasis,and prognosis of many kinds of malignant tumors.This article will review the literature on the formation of NETs and its effect on diffuse large B-cell lymphoma(DLBCL).