摘要
In general terms,the acute inflammatory reaction in conditions of infection or tissue damage is a response of the immune system to cope with survival and return to homeostasis.Temporarily,the reaction is initiated by edema followed by the progressive accumulation of polymorphonuclear leukocytes(PMN)and monocytes that differentiate into macrophages,with production of pro-inflammatory mediators such as leukotrienes(e.g.,LTB4)and prostaglandins(e.g.,PGE2,PGI2,PGF2),which in excess may progress to chronic inflammation(1).Considering that the acute inflammatory response is a protective and self-limited phenomenon,its resolution is an active programmed reaction that is set in by specific pro-resolving mediators(SPMs),which are derived from n-3 polyunsaturated fatty acids(n-3 PUFAs).
