乙酰半胱氨酸联合PDCA循环法治疗小儿支原体肺炎的临床疗效及其对免疫功能的影响

Clinical efficacy of acetylcysteine combined with PDCA circulation method in the treatment of mycoplasma pneumonia in children and its influence on immune function

目的探讨乙酰半胱氨酸联合PDCA循环法对小儿支原体肺炎的临床疗效及其对免疫功能的影响。方法以2018年6月至2020年6月辽宁省人民医院儿科病房收治的支原体肺炎患儿为研究对象,共108例,经随机数字表法分为2组。对照组54例予以基础治疗,观察组在对照组的基础上,予乙酰半胱氨酸雾化吸入联合PDCA循环法,连续治疗2周。比较两组患儿临床症状消失时间及住院时间,IgA、IgM、IgG等免疫功能指标变化,MDA、SOD及GSH-Pxy氧化应激指标变化及临床疗效。结果治疗后,两组患儿免疫功能指标均有所改善,其中IgA及IgG升高,IgM降低,与同期对照组相比,观察组免疫功能指标改善明显(P<0.05);治疗后两组患儿氧化应激指标均有所改善,其中MDA水平降低,SOD和GSH-Pxy水平升高(P<0.05);与同期对照组相比,观察组氧化应激指标变化显著(P<0.05);观察组患儿临床症状消失时间均显著短于对照组(P<0.05);观察组临床有效率为94.40%,显著高于对照组的77.78%(P<0.05)。结论乙酰半胱氨酸联合PDCA循环法用于小儿支原体肺炎的治疗中,能够改善患儿临床症状,提高免疫功能,缩短治疗周期,减轻氧化应激反应,提高临床疗效。

Objective To explore the clinical efficacy of acetylcysteine combined with PDCA circulation method in the treatment of mycoplasma pneumonia in children and its influence on immune function.Methods From June 2018 to June 2020,the patients with mycoplasma pneumonia in pediatric ward of Liaoning Provincial People′s Hospital were screened, and 108 cases were finally included.All the patients were randomly divided into two groups according to the random number table method.Patients in the control group were treated with routine treatment for 2 weeks.Patients in the observation group were treated with acetylcysteine atomization inhalation combined with PDCA circulation on the basis of routine treatment for 2 weeks.The disappearance time of clinical symptoms and hospitalization time, the changes in immune function indexes such as IgA,IgM and IgG,the changes in oxidative stress indexes such as MDA,SOD and GSH-Pxy and the clinical curative effect were observed.Results After treatment, the levels of immune function indexes in the two groups were improved, in which IgA and IgG increased and IgM decreased, and the changes of the above indexes in the observation group were more significant than those in the control group at the same time(P<0.05).After treatment, the levels of oxidative stress indexes in the two groups were improved, in which SOD and GSH-Pxy increased and MDA decreased(P<0.05),and the changes of the above indexes in the observation group were more significant than those in the control group at the same time(P<0.05).The disappearance time of clinical symptoms in the observation group was significantly shorter than that in the control group(P<0.05).The clinical effective rate of the observation group was 94.40%,which was significantly higher than that of the control group(77.78%,P<0.05).Conclusion Acetylcysteine combined with PDCA circulation method in the treatment of mycoplasma pneumonia in children can improve the clinical symptoms of children, improve immune function, shorten the treatment cycle, reduce oxidative stress response and effectively improve the curative effect.