BDH2基因在代谢与肿瘤发生发展中的作用与机制

Role and Mechanism of BDH2 Gene in Metabolism,Tumorigenesis and Progression of Cancer

肿瘤中的细胞代谢是促进肿瘤发生发展的重要生物学过程,代谢相关的基因正逐渐成为肿瘤治疗的靶点,但对肿瘤进展中的异常代谢及其预后价值仍需要大量研究挖掘。BDH2基因是一种多功能基因,参与多种代谢途径,在铁代谢中起重要的催化合成作用,同时参与酮体代谢并与脂代谢相关。近年来,研究者发现BDH2在不同类型的肿瘤中发挥的作用并不相同,多种肿瘤的发生发展与BDH2密切相关,本文对BDH2在代谢与肿瘤发生中的作用与机制进行分析、总结与展望。

Cellular metabolism in tumor is an important biological process to promote the occurrence and development of tumor,and the genes related to cellular metabolism are gradually becoming the targets of tumor treatment.However,more researches are still needed to explore the abnormal metabolism in tumor progression and its prognostic value.BDH2 gene is a multifunctional gene,participates in a variety of metabolic pathways,plays an important catalytic role in iron metabolism,participates in ketone metabolism and is related to lipid metabolism.In recent years,researchers have found that BDH2 plays distinct roles in various types of tumors.The occurrence and development of a variety of tumors are closely related to BDH2.This paper analyzes,summarizes and prospects the role and mechanism of BDH2 in metabolism and tumorigenesis.