T淋巴细胞及B淋巴细胞在糖尿病肾病发病机制中的作用

Role of T cells and B cells in the pathogenesis of diabetic nephropathy

糖尿病肾病(DN)是糖尿病的主要并发症之一,也是目前引起全球终末期肾病的最常见原因。传统上认为,DN的主要发病机制是代谢紊乱、血流动力学改变、氧化应激等。然而,近年来越来越多的证据表明,免疫细胞介导的慢性炎症反应在DN的发病过程中起重要作用。其中淋巴细胞与DN的病理过程密切相关,T淋巴细胞、B淋巴细胞可通过产生促炎症因子损伤肾组织,且T细胞通过CD4和CD8亚群的不同机制参与DN的发生发展。这些发现有助于确定该疾病新的治疗靶点。

Diabetic nephropathy(DN)is one of the major complications of diabetic mellitus and is currently the most common cause of end-stage renal disease worldwide.Traditionally,the main pathogenesis of DN is metabolic disturbance,hemodynamic changes,oxidative stress and so on.However,in recent years,more and more evidence shows that immune cell-mediated chronic inflammatory response plays an important role in the pathogenesis of DN.Lymphocytes are closely related to the pathological process of DN.T cells and B cells can lead to renal injury by producing pro-inflammatory factors,and T cells participate in the occurrence and development of DN through different mechanisms of CD4 and CD8 subsets.These findings help to identify new therapeutic targets for the disease.