Biodegradable polymer hydrogel-based tissue adhesives:A review

Tissue-adhesive materials are emerging biomaterials with potential applications in wound healing patches,tissue sealants,and haemostat materials.Tissue adhesives based on synthetic polymers generally have good adhesion but are not biodegradable.However,the long-term presence of non-biodegradable adhesives in the body can cause secondary harm to the patient.An ideal tissue adhesive should meet the following requirements:good adhesiveness,biodegradability,low cytotoxicity,and minimal inflammatory response.Natural polymers with inherent biodegradation and biocompatibility show great potentials in biomedical engineering,and the development of tissue adhesives based on natural polymers has become a hot topic in biomaterials science.This review systemat-ically summarises the latest progresses in biodegradable tissue adhesives based on natural polymers,such as chitosan,hyaluronic acid,alginate,gelatin,dextran,and cellulose.Methods for preparing natural polymer tissue adhesives are summarised and their ad-vantages and disadvantages are discussed.Finally,potential trends in the future direction of biodegradable tissue adhesives are discussed.