摘要
The natural ligament-bone interface features gradient changes in matrix composition,architecture and cell phenotype,which play critical roles in reliable ligament fixation and smooth loading transfer.Mimicking such organisations in artificial composite tissue-engineering scaffolds is important for realising functional fixation between ligament implants and host bones.Here,the authors aim to provide a comprehensive review on the latest strategies to fabricate biomimetic composite scaffolds for the regeneration of ligament-to-bone interface.The biomimetic composite scaffolds are divided into stratified and gradient scaffolds,which are characterised as layer-specific and continuous changes,respectively,in scaffold materials and/or microstructures.Biofabrication strategies for different types of composite scaffolds are summarised.The effects of material/structural changes on cellular morphology,cell differentiation,in vivo osteointegration and multi-tissue interface regeneration are highlighted.Finally,the potential challenges and future perspectives in engineering biomimetic composite scaffolds for ligament-bone interface regeneration are discussed.
基金
The Youth Innovation Team of Shaanxi Universities
the National Key Research and Development Program of China,Grant/Award Number:2018YFA0703000
the Fundamental Research Funds for the Central Universities
Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2020B1515130002
the Key Research Project of Shaanxi Province,Grant/Award Numbers:2020GXLH-Y-021,2021GXLH-Z-028
the Basic Research Program of Natural Science in Shaanxi Province,Grant/Award Number:2021JQ-906
the National Natural Science Foundation of China,Grant/Award Number:81601937。
