氨磺必利联合艾司西酞普兰治疗伴有焦虑症状的抑郁症的效果

Efficacy of Amisulpride Combined with Escitalopram in the Treatment of Depression with Anxiety

目的探讨氨磺必利联合艾司西酞普兰治疗伴有焦虑症状的抑郁症的效果。方法将2019年1月至2020年12月河南省洛阳荣康医院收治的88例伴有焦虑症状的抑郁症患者采用随机数表法分为研究组(44例)和对照组(44例)。对照组接受艾司西酞普兰片口服治疗,研究组在对照组治疗基础上加用氨磺必利片口服治疗。对比治疗前以及治疗后第8周末对照组与研究组的密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评分情况,并采用不良反应量表(TESS)评估不良反应。分别于治疗前后检测游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)水平变化。结果两组患者在治疗后第8周末HAMA、HAMD评分降低,且研究组低于对照组(P<0.05);治疗后研究组FT3及TSH水平高于治疗前(P<0.05)。结论氨磺必利联合艾司西酞普兰治疗伴有焦虑症状的抑郁症效果明显,无新的或其他严重不良反应。

Objective To explore the effect of amisulpride combined with escitalopram in the treatment of depression with anxiety.Methods Eighty-eight patients with depression and anxiety in Luoyang Rongkang Hospital from January 2019 to December 2020 were retrospectively analyzed and divided into an observation group and a control group using a random number table,44 cases in each group.The control group was given escitalopram tablets orally,and the study group was given amisulpride on the basis of the control group.The Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)scores before treatment and at the eighth weekend after treatment were compared.The levels changes of free triiodothyronine(FT 3),free tetraiodothyronine(FT 4),thyroid-stimulating hormone(TSH)and adverse reactions were measured before and after treatment.Results The HAMA and HAMD scores of the two groups of patients at the end of 8 weekends after treatment were lower than those before treatment(P<0.05).The HAMD and HAMA scores in the study group were lower than those in the control group(P<0.05).The levels of FT 3 and TSH in the observation group after treatment were higher than before treatment(P<0.05).Conclusion Amisulpride combined with escitalopram is effective in treating depression with anxiety with no new or other serious adverse reactions.