果酸治疗藏族人群面部轻、中度痤疮356例临床疗效分析

Clinical efficacy of Alpha Hydroxy Acids in the treatment of 356 cases of facial mild and moderate acne in Tibetan population

目的回顾性分析西藏高原地区356例面部轻、中度痤疮中果酸治疗的临床疗效及相关不良反应,探索高原地区痤疮果酸治疗的最优方案。方法选取符合诊断标准的某院门诊面部轻、中度痤疮患者356例为研究对象,行果酸治疗,每两周一次,四次为一个疗程,观察临床疗效、统计治疗中、治疗后的不良反应。结果患者第3周,第5周、第7周、第9周的总疗效分别为68.8%、76.7%、84.0%和93.8%,呈明显上升趋势。经过前三次治疗,刺痒、灼热、轻微浅红斑、中度红斑的发生率轻度升高,第4次治疗后,自觉症状和皮肤反应下降;然而,“刺痛症状”发生率在治疗的整个阶段中一直下降。无病例出现重度红斑反应。结论果酸换肤治疗藏族人群面部轻、中度痤疮的效果明显,安全性好,值得在高原地区推广。

Objective To retrospectively analyze the clinical efficacy and related adverse reactions of Alpha Hydroxy Acids in 356 cases of facial mild-moderate acne in Tibet Plateau,and to explore the optimal scheme of Alpha Hydroxy Acids treatment of acne in Tibet Plateau.Methods 356 patients with facial mild or moderate acne in our hospital were selected to participate in this study.They were treated with Alpha Hydroxy Acids once every two weeks and four times as a course of therapy.The clinical efficacy was observed and the adverse reactions during and after treatment were counted.Results The total efficacy of the patients at the 3rd,5th,7th and 9th weeks were 68.8%,76.7%,84.0% and 93.8% respectively,showing a significant upward trend.After the first three treatments,the incidence of itching,burning,slight light erythema and moderate erythema increased gradually.However,after the fourth treatment,the conscious symptoms and skin reactions finally decreased;During the whole therapy,the rate of“stinging symptoms”had decreased.No severe erythema reaction occurred.Conclusion Alpha Hydroxy Acids skin replacement is effective and safe in the treatment of mild and moderate facial acne in Tibetan population.It is worthy to be used in plateau areas.