艾滋病低病毒血症的影响因素及临床意义研究进展

Advanced review of influencing factors and clinical significance of Low-level HIV viremia

目前对于艾滋病低病毒血症的定义仍没有统一的共识,不同研究对于同一临床影响因素得到的结果也不完全相同。现将近年来国内外对低病毒血症的研究进行综述,总结与其有关的临床影响因素及其临床危害。通过现有论著结果表明抗病毒治疗前的CD_(4)^(+)T淋巴细胞水平、基线病毒载量、抗病毒治疗依从性可能是低病毒血症的影响因素。艾滋病低病毒血症也会增加病毒学治疗失败的风险,从而增加病毒传播的风险。临床医生必须密切关注低病毒血症的危害及其影响因素,对有相关危险因素的患者进行密切随访做到及时处理,以防止艾滋病低病毒血症的发生。

There is still no unified consensus on the definition of Low-level HIV viremia(LLV).The results of different studies obtained for the same clinical influencing factors are not exactly the same.Recent studies on LLV at home and abroad are reviewed to summarize the clinical influencing factors related to it and its clinical hazards.The results of the existing papers show that the preantiviral treatment,the level of CD_(4)^(+)T lymphocytes,baseline viral load,and compliance with antiviral therapy may be the influencing factors of Low-level viremia.LLV will also increase the risk of virological treatment failure,thereby increasing the risk of virus transmission.Clinicians must pay attention to the hazard and influencing factors of Low level viremia.Patients with risk factors should be closely followed up and dealt with in time to prevent the occurrence of Low-level viremia.