痤疮与皮肤微生物

Acne and skin microbiota

痤疮的四大发病机制是皮脂腺过量分泌脂质、毛囊皮脂腺导管角化异常、痤疮丙酸杆菌等皮肤微生物增殖、发炎与免疫反应。本文结合国内外研究进展,对痤疮的发病机制中皮肤常驻微生物,包括痤疮丙酸杆菌、表皮葡萄球菌、马拉色菌的作用进行综述,同时综述耐药性痤疮丙酸杆菌的耐药机制,及在耐药率不断升高下,替代治疗以及物理疗法的发展。

The major pathogenesis of acne vulgaris(acne)include increased in sebum production,follicular hyperkeratinization,colony formation of Cutibacterium acnes,inflammation and immune response.Combined with the research advanced at domestic and abroad,this paper summarized the role of skin commensal microorganisms,including Cutibacterium acnes,Staphylococcus,Malassezia spp.,in the pathogenesis of acne.Moreover,we summarized the drug resistance mechanism of drugresistant Cutibacterium acnesand thedevelopment of alternative therapy,including the use of microbial interactions and physical therapy.