生物钟与皮肤病的关系

The relationship between the biological clock and skin diseases

在长期的进化过程中,地球上多种生物的生理生化过程,形成了以24小时为周期的节律性变化。生物钟通过整合自然界的时间信息,使各生物的生理行为与环境同步,这就形成了昼夜节律。大量研究表明生物钟基因参与了睡眠-觉醒周期、新陈代谢、激素的分泌、体温的变化以及各种免疫反应等,且昼夜节律的紊乱与心血管疾病、内分泌疾病、癌症、皮肤病等的发生发展密切相关。本文就生物钟与皮肤病的关系作一综述。

The physiological and biochemical processes of many organisms on earth have formed a 24-hour cycle of rhythmic changes in the long-term evolution process.By integrating the time information of nature,the biological clock synchronizes the physiological behavior of various organisms with the environment,which forms the circadian rhythm.A large number of studies have shown that biological clock genes are involved in the sleep-wake cycle,metabolism,hormone secretion,changes in body temperature,and various immune responses,etc.,and circadian rhythm disorders are closely related to the occurrence and development of cardiovascular diseases,endocrine diseases,cancer,and skin diseases.This article reviews the relationship between the biological clock and skin diseases.