无创脑刺激对阿尔茨海默病精神行为症状治疗的研究进展

Progress of noninvasive brain stimulation in the treatment of Behavioral and Psychological Symptoms of Dementia in Alzheimer's disease

阿尔茨海默病(Alzheimer's disease,AD)是老年人中最常见的痴呆类型,往往伴随着很多痴呆的精神与行为症状(behavioral and psychological symptoms of dementia,BPSD)。近年来,不同类型的无创性脑刺激(noninvasive brain stimulation,NIBS)技术被广泛用于AD患者的治疗,先前大量的研究表明,经颅直流电刺激(transcranial direct current stimulation,tDCS)和重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)都能显著改善AD患者的认知功能。然而,关于NIBS对AD患者BPSD治疗的研究相对较少,结果仍然存在争议。本文就tDCS和rTMS对AD患者BPSD治疗的研究进展做综述。

Alzheimer's disease(AD)is the most common type of dementia in the elderly,which is often accompanied by many behavioral and psychological symptoms of dementia(BPSD).Recently,different types of noninvasive brain stimulation(NIBS)have been widely used in the treatment of AD patients.Many previous studies both have shown that transcranial direct current stimulation(tDCS)and repetitive transcranial magnetic stimulation(rTMS)can significantly improve the cognitive function of AD patients.However,there are few studies about NIBS for the treatment of BPSD in AD patients,and the results are still inconsistent In this paper,the progress of tDCS and rTMS in the treatment of BPSD in AD patients will be reviewed.