血凝酶联合奥美拉唑对急性非静脉曲张上消化道出血患者血红蛋白及应激反应水平的影响

The Effect of Hemagglutinin Combined with Omeprazole on Hemoglobin and Stress Response in Patients with Acute Non-varices Upper Gastrointestinal Bleeding

目的:探讨血凝酶联合奥美拉唑治疗急性非静脉曲张上消化道出血(Acute non-varicose upper gastrointestinal bleeding,ANVUGIB)的临床效果及对血红蛋白、应激反应水平的影响。方法:选取九江市第三人民医院2019年1月至2021年1月收治的82例ANVUGIB患者,按随机数字表法分为两组,各41例。两组均接受常规治疗,对照组加用奥美拉唑治疗,观察组于对照组基础上予以血凝酶治疗。比较两组临床疗效、血红蛋白(Hb)水平与止血时间、应激反应水平及不良反应情况。结果:观察组治疗总有效率为95.12%高于对照组的80.49%,差异有统计学意义(P<0.05);观察组Hb高于对照组,止血时间短于对照组,差异有统计学意义(P<0.05);观察组治疗后皮质醇(COR)和肿瘤坏死因子-α(TNF-α)水平低于对照组,差异有统计学意义(P<0.05);两组不良反应相比,差异无统计学意义(P>0.05)。结论:血凝酶联合奥美拉唑可增强ANVUGIB治疗效果,缩短止血时间,并减轻应激反应水平,加快病情好转,且安全性高。

Objective:To investigate the clinical effect of hemagglutinin combined with omeprazole in the treatment of acute non-varices upper gastrointestinal bleeding(ANVUGIB)and its influence on hemoglobin and stress response levels.Methods:A total of 82 ANVUGIB patients admitted to The Third People's Hospital of Jiujiang City from January 2019 to January 2021 were selected and divided into two groups according to the random number table method,with 41 cases in each group.Both groups received conventional treatment,the control group was treated with omeprazole,and the observation group was treated with hemagglutinin on the basis of the control group.The clinical efficacy,hemoglobin(Hb)level and hemostasis time,stress response level and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.12%,which was higher than 80.49%in the control group,which was statistically different(P<0.05).The Hb of the observation group was higher than that of the control group,and the hemostasis time was shorter than that of the control group,which was statistically different(P<0.05).After treatment,the levels of cortisol(COR)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and there was a statistical difference(P<0.05).There was no statistical difference between the two groups of adverse reactions(P>0.05).Conclusion:The combination of hemagglutinin and omeprazole can enhance the therapeutic effect of ANVUGIB,shorten the time of hemostasis,reduce the level of stress response,accelerate the improvement of the condition,and have high safety.