切开引流挂线术联合甲硝唑与左氧氟沙星治疗肛周脓肿38例

Effect of Incision,Drainage and Thread Drawing Combined with Metronidazole and Levofloxacin in the Trematment of 38 Cases of Perianal Abscess

目的:探讨切开引流挂线术联合甲硝唑与左氧氟沙星在肛周脓肿患者中的应用价值。方法:选择2019年1月至2021年1月九江市第三人民医院收治的肛周脓肿患者76例,按随机数字表法分为两组,各38例。对照组采用切开引流挂线术,研究组在对照组基础上采用甲硝唑+左氧氟沙星治疗。比较两组炎症因子水平、疼痛程度、创面愈合情况、复发率。结果:治疗前,两组C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、巨噬细胞(CD68)相比,差异无统计学意义(P>0.05);治疗后,研究组CRP、SAA、CD68均低于对照组,差异有统计学意义(P<0.05);研究组视觉模拟评分法(VAS)评分及复发率低于对照组,创面腐肉脱落、创面愈合时间短于对照组,差异有统计学意义(P<0.05)。结论:切开引流挂线术联合甲硝唑与左氧氟沙星能够减轻肛周脓肿患者机体炎症反应及疼痛,加快创面愈合,且复发率较低,值得临床推广应用。

Objective:To explore the application value of incision,drainage and thread drawing combined with metronidazole and levofloxacin in patients with perianal abscess.Methods:76 patients with perianal abscess admitted to The Third People's Hospital of Jiujiang City from January 2019 to January 2021 were selected and divided into two groups according to the random number table method,with 38 cases in each group.The control group was treated with incision,drainage and thread-drawing,and the study group was treated with metronidazole+levofloxacin on the basis of the control group.The levels of inflammatory factors,pain degree,wound healing,and recurrence rate were compared between the two groups.Results:Before treatment,there was no significant difference between the two groups of C-reactive protein(CRP),serum amyloid A(SAA),and macrophages(CD68)(P>0.05).After treatment,the study group's CRP,SAA and CD68 were lower than the control group,the difference was statistically significant(P<0.05).The visual analogue scoring(VAS)score and recurrence rate of the study group were lower than those of the control group,the difference was statistically significant(P<0.05).Conclusion:Incision drainage and thread drawing combined with metronidazole and levofloxacin can reduce the inflammation and pain of patients with perianal abscess,accelerate wound healing,and have a low recurrence rate.It is worthy of clinical application.