中医外治法治疗非酒精性脂肪肝的研究进展

Research progress of external therapies of traditional Chinese medicine in the treatment of non-alcoholic fatty liver disease

非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)是一种以弥漫性肝细胞脂肪变性为主要特征的常见慢性肝病,随着人们生活水平的提高,NAFLD的发病率不断增长,已经成为21世纪全球健康问题之一。然而,目前尚无治疗NAFLD的特效药物以及公认的标准化治疗方案,这也为临床治疗带来了挑战。基于中医特色的针刺、艾灸、推拿等中医外治法在临床治疗NAFLD中的疗效明显,但其机制并未系统阐释,临床推广证据不足。本文拟通过总结近年来国内外中医外治法治疗NAFLD的相关研究,分析其可能的作用机制,从而为今后基础实验和临床研究提供科学的理论依据,以期在未来形成一整套具有中医特色的标准化临床诊疗方案。

Non-alcoholic fatty liver disease(NAFLD)is a common chronic liver disease characterized by diffuse hepatic steatosis. With the improvement of people’s living standard,the incidence rate of NAFLD has been increasing,which has become one of the global health problems in 21st Century. However,there is no specific drug or standard treatment for NAFLD,which brings challenges to the treatment. Acupuncture,moxibustion,massage and other external therapies based on the characteristics of traditional Chinese medicine have obvious curative effect in the clinical treatment of NAFLD,but the mechanism has not been systematically explained,which makes the clinical promotion evidence insufficient. This paper aims to summarize the researches on the treatment of NAFLD by external therapies of traditional Chinese medicine in recent years,and analyze its possible mechanism,so as to provide a scientific theoretical basis for future basic experiments and clinical research,and form a set of standardized clinical diagnosis and treatment scheme with the characteristics of traditional Chinese medicine.