外泌体及其内容物对胃癌发生、发展的作用

Effects of Exosomes and Their Contents on Pathogenesis and Development of Gastric Cancer

胃癌是全球范围内多发的恶性肿瘤,是严重威胁人类健康的疾病之一。胃癌是一种多因素导致的疾病,外泌体在包括胃癌在内的多种恶性肿瘤的发生、发展中扮演着关键角色。外泌体可通过转运特定的外泌体内容物来调节局部和远处的细胞通讯,亦可通过调节肿瘤细胞生长增殖、肿瘤相关免疫功能以及肿瘤血管生成,促进或抑制胃癌的发生、发展。本文就外泌体及其内容物对胃癌发生、发展的作用作一综述。

Gastric cancer is a malignant tumor with worldwide high incidence and threatening the human health severely.It is a disease induced by multiple factors.Exosomes play an important role in the pathogenesis and development of many malignant tumors including gastric cancer.Exosomes can transport specific contents to regulate local and distant cell communications,and are able to promote or inhibit the development of gastric cancer through regulating the growth and proliferation of tumor cells,relevant immune function and angiogenesis of tumors.This article reviewed the effects of exosomes and their contents on the pathogenesis and development of gastric cancer.