孟鲁斯特钠治疗小儿哮喘的临床研究

Study on the Clinical Effect of Montelukast Sodium in the Treatment of Childhood Asthma

目的:探讨哮喘患儿使用孟鲁斯特钠治疗的临床治疗效果。方法:选取2018年6月至2019年6月在平顶山市第四人民医院进行诊治的78例哮喘患儿,运用随机数字表法将其平均分为两组,自然组和研究组各39例。自然组患儿给予常规方式治疗,研究组患儿在此基础上采用孟鲁斯特钠治疗。对两组患儿治疗前及治疗6个月后的哮喘症状评分以及肺功能评分、尿白三烯监测水平、血氧分压、血二氧化碳分压、免疫球蛋白E、嗜酸性粒细胞计数、C反应蛋白水平的变化情况,以及两组患儿不良反应发生情况、咳嗽缓解时间、喘息缓解时间、哮鸣音消失时间、哮喘急性发作次数、急诊次数、临床治疗总有效率进行比较。结果:研究组患儿的不良反应发生率明显低于自然组,差异具有统计学意义(P<0.05);研究组患儿的临床治疗总有效率明显高于自然组,差异具有统计学意义(P<0.05);相比于治疗前,治疗6个月后研究组患儿的哮喘症状评分、尿白三烯监测水平、血二氧化碳分压、免疫球蛋白E、嗜酸性粒细胞计数、C反应蛋白水平明显降低,肺功能评分、血氧分压明显提升,且与自然组相比,差异均具有统计学意义(P<0.05);研究组患儿的咳嗽缓解时间、喘息缓解时间、哮鸣音消失时间明显短于自然组,哮喘急性发作次数、急诊次数明显少于自然组,差异具有统计学意义(P<0.05)。结论:哮喘患儿使用孟鲁斯特钠治疗具有良好的效果,不仅能够提升肺功能评分、血氧分压与临床治疗总有效率,同时还能够降低哮喘症状评分、不良反应发生率、尿白三烯监测水平、血二氧化碳分压、免疫球蛋白E、嗜酸性粒细胞计数、C反应蛋白水平,缩短咳嗽缓解时间、喘息缓解时间、哮鸣音消失时间,减少哮喘急性发作次数及急诊次数。

Objective To study and explore the clinical therapeutic effect of montelukast sodium in children with asthma.Methods 78 children with asthma treated in Pingdingshan Fourth People’s Hospital from June 2018 to June 2019 were randomly divided into natural group and research group,39 cases in each group.Children in the natural group received conventional treatment,and children in the research group received montelukast sodium treatment on this basis.The asthma symptom score and pulmonary function score,urinary leukotriene monitoring level,blood oxygen partial pressure,blood carbon dioxide partial pressure,immunoglobulin E,eosinophil count and C-reactive protein level before and 6 months after treatment,occurrence of adverse reactions,cough relief time situation,wheezing relief time situation,wheezing disappearance time situation,the number of acute attacks of asthma,the number of emergency cases and the total effective rate of clinical treatment between the two groups were compared.Results The incidence of adverse reactions in the research group was significantly lower than that in the natural group(P < 0.05);The total effective rate of clinical treatment in the research group was significantly higher than that in the natural group (P < 0.05);Compared with before treatment,after 6 months of treatment,the asthma symptom score,urinary leukotriene monitoring level,blood carbon dioxide partial pressure,immunoglobulin E,eosinophil count and C-reactive protein level of children in the research group decreased significantly,and the pulmonary function score and blood oxygen partial pressure increased significantly compared with the natural group (P < 0.05);The cough relief time,wheezing relief time and wheezing disappearance time of children in the research group were significantly shorter than those in the natural group,and the number of acute attacks and emergency cases of asthma were significantly less than those in the natural group (P < 0.05).Conclusion Montelukast sodium has a good effect on children with asthma.It can not only improve the pulmonary function score,blood oxygen partial pressure and the total effective rate of clinical treatment,but also reduce the asthma symptom score,the incidence of adverse reactions,the level of urinary leukotriene monitoring,blood carbon dioxide partial pressure,immunoglobulin e,eosinophil count and C-reactive protein,shorten the cough relieftime,wheezing relief time and wheezing disappearance time,and reduce the number of acute attacks and emergency cases of asthma.