几种药食同源植物来源中药肝毒性机制研究进展

Research progress in hepatotoxicity mechanism of several traditional Chinese medicines from medicine and food homology plants

药食同源植物在《食品安全法》中被称为“按照传统既是食品又是中药材的物质”,被广泛应用于日化产品、保健食品和日常饮食。现中华人民共和国国家卫生健康委员会公布的药食同源资源共110种,其中药食同源植物共99种,其中部分植物可造成肝损伤。本文主要概括薄荷、栀子、肉桂、决明子和白果等几种药食同源植物来源中药通过氧化应激途径、线粒体途径和P450酶系代谢途径等造成肝损伤的主要作用机制,以期为药食同源植物的合理安全用药提供科学指导,对其在食疗、药用及保健等领域的深入研究提供参考资料。

"Medicine and food homology"plants are defined as"substances that are both food and traditional Chinese medicinal materials"in the Food Safety Law,and are widely used in the treatment of diseases and daily diet.So far,the National Health Committee of the People′s Republic of China has announced a total of 110 kinds of medicine and food homology resources,including 99 kinds of medi⁃cine and food homology plants.It is found that some plants may cause damage to the liver.This article summarizes the main mechanism of liver injury caused by several"medicine and food homology"plants such as Menthea Haplocalycis Herba,Gardeniae Fructus,Cinnamomi Cortex,Cassiae Semen,Ginkgo Semen through oxidative stress pathway,mitochondrial pathway and cytochrosome P450 enzyme metabolic pathway in order to give tips about rational and safe use of medicine and food homology plants and provide data for the medicinal and edible plant diet,medical and health research.