基于中医传承辅助平台探析郑惠芳治疗痛经用药规律

Analysis of Medication Regularity of ZHENG Huifang in Treating Dysmenorrhea Based on Traditional Chinese Medicine Inheritance Platform

目的:应用数据挖掘方法对郑惠芳教授治疗痛经的用药规律进行分析。方法:通过收集病例,整理郑惠芳教授治疗痛经的相关有效处方,对高频药物、高频药物组合、关联规则、新处方组合、四气五味、归经进行数据挖掘,总结郑惠芳教授治疗痛经的用药规律。结果:本研究共纳入264首郑惠芳教授治疗痛经的中药处方,分析得出高频用药13味,前10位分别为白芍、丹参、甘草、桃仁、当归、香附、茯苓、桂枝、延胡索、陈皮;高频药物组合有30组,前5位分别是丹参-桃仁、丹参-白芍、桃仁-白芍、延胡索-香附、桃仁-香附;关联规则分析结果显示延胡索、白芍、丹参→香附与延胡索、赤芍、丹参、桃仁→香附为关联度最高的组合,由此进一步推演出新处方组合8种;用药四气五味与归经分析显示药物性偏温、平,甘、苦、辛味药多见,多归为肝、脾、心经。结论:郑惠芳教授治疗痛经以活血化瘀为主,同时配伍调肝化瘀、理气止痛药物,多用辛、甘、温、苦之品。

Objective:Data mining method was applied to analyze the medication regularity of Professor ZHENG Huifang in the treatment of dysmenorrhea.Methods:Relevant effective prescriptions of Professor ZHENG Huifang in treating dysmenorrhea were sorted out through collecting cases.Data mining is carried out for high-frequency herbs,high-frequency drug combinations,association rules,new prescription combination,four qi and five tastes,meridian to summary medication regularity of Professor ZHENG Huifang’s in treating dysmenorrhea.Results:In this study,a total of 264 prescriptions of Professor ZHENG Huifang in treating dysmenorrhea were included,and 13 high-frequency herbs were analyzed.The top 10 herbs were Baishao(Paeoniae Radix Alba),Danshen(Salviae Mil Tiorrhizae Radix Et Rhizoma),Gancao(Glycyrrhizae Lycyrrhizae Radix Et Rhizoma),Taoren(Persicae Semen),Danggui(Angelicae Sinensis Radix),Xiangfu(Cyperi Rhizoma),Fuling(Poria),Guizhi(Cinnamomi Ramulus),Yanhusuo(Corydalis Rhizoma),Chenpi(Citri Reticulatae Pericarpium).There were 30 kinds of high-frequency drug combinations,and the top 5 were Danshen-Taoren,Danshen-Baishao,Taoren-Baishao,Yanhusuo-Xiangfu,Taoren-Xiangfu.Association rule analysis showed that Yanhusuo,Baishao,Danshen→Xiangfu and Yanhusuo,Chishao(Paeoniae Radix Rubra),Danshen,Taoren→Xiangfu had the highest correlation.From this,8 new prescription combinations were further developed.The analysis of the four qi and five tastes and the meridian showed that most of the medicinals were warm,mild,sweet,bitter and pungent,which mostly enters liver,spleen and heart meridian.Conclusions:In the treatment of dysmenorrhea,Professor ZHENG Huifang insists on promoting blood circulation and removing blood stasis,and the treatment attaches importance to regulating the liver and removing blood stasis,regulating qi and relieving pain with medicinals which are warm,mild,sweet,bitter and pungent.