顺铂时辰化疗同步放疗治疗局部晚期宫颈癌的临床观察

Clinical observation of chronomodulated cisplatin chemotherapy and concurrent radiotherapy in locally advanced cervical cancer

目的观察顺铂时辰化疗同步放疗治疗局部晚期宫颈癌的效果。方法80例局部晚期宫颈癌患者分别采用顺铂常规化疗同步放疗(对照组)、顺铂时辰化疗同步放疗(观察组)。比较两组近期疗效、免疫功能、Karnofsky功能状态(KPS)评分、不良反应及。结果两组患者近期疗效比较差异无统计学意义(P>0.05)。观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)值及KPS评分明显高于对照组(P<0.05),而总消化道反应、Ⅰ~Ⅱ度和总骨髓抑制发生率均明显低于对照组(P<0.05)。结论顺铂时辰化疗同步放疗治疗局部晚期宫颈癌对患者细胞免疫功能和健康状况影响较小,不良反应较少。

Objective To observe the efficacy of cisplatin chronomodulated chemotherapy(CCT)and concurrent radiotherapy(CRT)in locally advanced cervical cancer(LACC).Methods Eighty LACC patients were treated with cisplatin conventional chemotherapy and CRT(control group)or cisplatin CCT and CRT(observation group).The short-term effect,immune function,Karnofsky performance status(KPS)and adverse reactions were compared between two groups.Results The short-term effect was comparable between two groups(P>0.05).Compared with control groups,CD3^(+)and CD4^(+)cells,CD4^(+)/CD8^(+)ratio,and KPS scores were higher(P<0.05),while total gastrointestinal reaction,grade I-II and overall myelosuppression were lower(P<0.05)in observation group.Conclusion Combined cisplatin CCT and CRT can exert little influence on immune function and health status and decrease adverse reactions in LACC patients.