卵巢成熟型囊性畸胎瘤伴类癌3例临床病理分析

Clinicopathologic analysis of mature cystic teratoma with carcinoid in ovaries

目的总结卵巢成熟型囊性畸胎瘤伴类癌的临床病理特征。方法回顾性分析3例卵巢成熟型囊性畸胎瘤伴类癌患者的临床病理资料及免疫组化结果。结果3例患者表现为附件囊实性包块。2例镜下为卵巢成熟型囊性畸胎瘤伴甲状腺肿类癌;另1例为卵巢成熟型囊性畸胎瘤伴类癌,未见甲状腺肿成分。免疫组化显示3例类癌区域CD56、Syn、CgA、Pan-CK、CDX2、1%~2%Ki67阳性,而2例甲状腺肿区域Pan-CK、TTF-1、CD56阳性。结论卵巢成熟型囊性畸胎瘤伴类癌是一种罕见的低度恶性肿瘤,其诊断主要依靠病理学特征及免疫组化结果。

Objective To summarize the clinicopathological features of mature cystic teratoma with carcinoid(MCTC)in ovaries.Methods Clinicopathological,and immunohistochemical data of 3 ovarian MCTC cases were retrospectively analyzed.Results Three cases presented with cystic/solid adnexal masses,of which 2 were MCT with strumal carcinoid,and 1 was MCTC.Immunohistochemistry showed that the carcinoid was positive for CD56,Syn,CgA,pan-CK,CDX2,and Ki67(1%-2%),while strumal carcinoid was positive for pan-CK,TTF-1 and CD56.Conclusion The ovarian MCTC is a rare low-grade malignant tumor.Its diagnosis mainly depend on pathological and immunohistochemical features.