摘要
Three new ursane-type triterpenoids,3-oxours-12-en-20,28-olide(1),3β-hydroxyurs-12-en-20,28-olide(2)and 3β-hydroxyurs-11,13(18)-dien-20,28-olide(3),were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis.Their structures were elucidated by a combination of extensive 1D-and 2D-NMR experiments,MS data and comparisons with literature reports.Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages,but no antibacterial activity was found at a concentration of 128μg·mL^(-1).
基金
supported by the Key Projects of Beijing Natural Sciences Foundation and Beijing Municipal Education Committee(No.KZ201811417049)
the Scientific Research Common Program of Beijing Municipal Commission of Education(No.KM202011417014)
the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province(No.2019-ZJ-Y19)
Beijing Union University Graduate Research and Innovation Fund Project(No.YZ2020K001)
the Academic Research Projects of Beijing Union University(No.XP202005)。
