老年高血压患者血清视黄醇结合蛋白水平与颈动脉病变的相关性分析

Correlation Between Serum Retinol Binding Protein Level and Carotid Artery Disease in Elderly Patients with Hypertension

目的:研究老年高血压患者血清视黄醇结合蛋白水平与颈动脉病变的相关性。方法:选取2016年1月-2020年12月广西桂林市第二人民医院全科医疗科及心血管内科老年高血压住院患者200例,年龄61~78岁,以颈动脉内膜中层厚度(IMT)为切点分为IMT正常组、IMT增厚组和IMT斑块组。分析血清视黄醇结合蛋白水平与颈动脉病变的关系。结果:IMT增厚组血清视黄醇结合蛋白水平高于IMT正常组,差异有统计学意义(P<0.05);IMT斑块组血清视黄醇结合蛋白高于IMT正常组及IMT增厚组,差异有统计学意义(P<0.05)。相关性分析表明,血清视黄醇结合蛋白和IMT为正相关。LogistiC回归分析结果显示,血清视黄醇蛋白水平是发生颈动脉硬化疾病的独立危险因素。结论:老年高血压患者血清视黄醇结合蛋白水平增高与颈动脉病变呈正相关。

Objective:To investigate the correlation between serum retinol binding protein level and carotid artery disease in elderly patients with hypertension.Methods:Between January 2016 and March 2020,200 elderly patients with hypertension who were hospitalized in Department of General Medicine and Department of Cardiology at the Second People's Hospital of Guilin were selected,including 108 males and 92 females,they aged 61-78 years.Carotid intima-media thickness(IMT)was used as the cut off point for grouping,and the patients were divided into normal IMT group,IMT thickening group and IMT plaque group.Results:The level of serum retinol binding protein level in the IMT thickening group was higher than that in the normal IMT group,and the difference was statistically significant(P<0.05).The level of serum retinol binding protein level in the IMT plaque group was higher than that in the normal IMT group and IMT thickening group,and the difference was statistically significant(P<0.05).Correlation analysis showed that serum retinol binding protein and IMT were positively correlated.Logistic regression analysis showed that serum retinol protein level was an independent risk factor for carotid atherosclerosis.Conclusion:The increase of serum retinol binding protein level in elderly patients with hypertension is positively correlated with carotid artery disease.