全身免疫炎症指数对慢性肾脏病非透析患者左心室肥厚的评估价值

Evaluation value of systemic immune inflammation index foRleft ventriculaRhypertrophy in non-dialysis patients with chronic kidney disease

目的探讨非透析的慢性肾脏病(CKD)患者左心室肥厚(LVH)的发生情况及相关危险因素,分析全身免疫炎症指数(SII)对LVH的评估价值。方法选取CKD患者196例为研究对象(CKD组),根据性别分为CKD男性组117例和CKD女性组79例,并选取同期40例健康者为对照组。收集并分析3组实验室指标及心脏超声资料。分析左心室质量指数(LVMI)与其他指标的相关性。采用Logistic回归分析LVH的危险因素,以及分析SII与LVH的关系。结果男性、女性LVH患病率分别为31.62%、50.63%。收缩压(SBP)升高、血红蛋白(Hb)降低、SII升高是男性患者LVH发生的独立危险因素,而高龄、Hb降低、尿酸(UA)上升是女性患者LVH发生的独立危险因素(P<0.05)。结论LVH在非透析的CKD患者中普遍存在,且女性患者较多。贫血是所有CKD患者LVH的危险因素,SII升高是男性患者LVH的危险因素。

Objective To investigate the incidence and risk factors of left ventriculaRhypertrophy(LVH)in non-dialysis patients with chronic kidney disease(CKD),and to analyze the value of systemic immune inflammation index(SII)in evaluating LVH.Methods A total of 196 non-dialysis patients with CKD were selected as study subjects(CKD group).According to gender,196 cases were divided into male CKD group(n=117)and female CKD group(n=79),and 40 healthy subjects in the same period were selected as control group.The laboratory indexes and cardiac ultrasound data of three groups were collected and analyzed.The correlation between left ventriculaRmass index(LVMI)and otheRindexes was analyzed.Logistic regression was used to analyze the risk factors of LVH and the relationship between SII and LVH(P<0.05).Results The prevalence of LVH in male and female was 31.62%and 50.63%,respectively.Increased systolic blood pressure(SBP),decreased hemoglobin(Hb)and increased SII were independent risk factors foRLVH in male patients,while oldeRage,decreased Hb and increased uric acid(UA)were independent risk factors foRLVH in female patients.Conclusion LVH is common in non-dialysis patients with CKD,and there are more female patients.Anemia is a risk factoRfoRLVH in all CKD patients while SII is a risk factoRfoRLVH in men.