摘要
Background:To investigate the associations of lens power with age,axial length(AL),and Type 2 diabetes mellitus(DM)in Chinese adults aged 50 and above.Methods:Random clustering sampling was used to identify adults aged 50 years and above in urban regions of Shanghai.The participants underwent a comprehensive ophthalmic examination including subjective refraction,autorefraction,and IOL-Master.The crystalline lens power was calculated using Bennett’s formula.Results:A total of 4177 adults were included.A linear decrease in lens power was observed both with age and with AL,followed by a stop of lens power loss after the age of 70 or when AL≥25 mm,respectively.Participants with Type 2 DM presented higher lens power(0.43 diopter(D),p<0.001)and thicker lens thickness(0.06 mm,p<0.001).In multivariate regression models,there was a positive correlation between lens power and Type 2 DM when age<75 years(p<0.001)or AL<25 mm(p<0.001)after adjusting for other factors,while no significant association was found in participants aged≥75 years(p=0.122)or with AL≥25 mm(p=0.172).Conclusions:The lens power in adults aged 50 and above exhibited two stages with age and with AL.Type 2 DM caused an increase in lens power,which was not seen in participants aged≥75 years or with AL≥25 mm.
基金
This study was funded by the National Natural Science Foundation of China(Grant No.:81670898 and 81703287,Beijing,China)
the Shanghai Three-Year Public Health Action Program(Project Nos.GWIV-3.3 and GWIV-13.1,Shanghai,China)
the Shanghai High-level Overseas Training Team Program on Eye Public Health(Project No.GWTD2015S08,Shanghai,China)
Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(Project No.20172022,Shanghai,China)
Shanghai General Hospital,Clinical Research(Project No.CTCCR-2018Z01,Shanghai,China)
the Shanghai Science and Technology Commission Research Project(Project No.17ZR1426900,Shanghai,China)
the Shanghai Municipal Planning Commission of Science and Research Fund(Project No.201640090,Shanghai,China)
National Key R&D Program of China(Project No.2016YFC0904800,2019YFC0840607)
National Science and Technology Major Project of China(Project No.2017ZX09304010)
The sponsors or funding organizations had no role in the design or conduct of this research.
