灰度比值在甲状腺实性结节的良恶性鉴别诊断中的应用价值

Value of Ultrasound Gray Scale Ratio in the Differential Diagnosis of Benign and Malignant Solid Thyroid Nodules

目的探讨甲状腺实性结节与正常甲状腺组织灰度比值在鉴别实性结节的良恶性方面的应用价值。方法选取行外科手术或在超声科行超声引导下甲状腺细针穿刺抽吸活检的患者共115例,共纳入132个结节,其中良性结节45个,恶性结节87个。采用Adobe Photoshop图像处理软件的“直方图”功能计算良性结节、恶性结节与周围甲状腺组织的灰度比值,比较二者差异;绘制受试者工作特征曲线(ROC曲线)分析灰度比值预测恶性结节的诊断效能。结果良性结节、恶性结节与周围甲状腺组织的灰度比值分别为(0.78±0.28)、(0.49±0.21),差异有统计学意义(P<0.05)。当灰度比值为0.605时,其鉴别良、恶性实性结节的敏感性79.1%,特异性75.1%,曲线下面积0.853。结论灰度比值在甲状腺良、恶性实性结节鉴别诊断中具有一定的临床应用价值。

Objective To explore the application value of ultrasound gray scale ratio in the differential diagnosis of benign and malignant solid thyroid nodules.Methods A total of 115 patients who underwent surgery or underwent ultrasound-guided fine-needle aspiration biopsy of the thyroid gland in the ultrasound department were selected.A total of 132 thyroid nodules were included,including 45 benign thyroid nodules and 87 malignant thyroid nodules.The ultrasound gray scale ratio of benign and malignant thyroid nodule to surrounding tissue was calculated by the histogram of the Adobe Photoshop software,and the difference was compared.The diagnostic efficiency of ultrasound gray scale ratio in predicting malignant thyroid nodules was analyzed by the receiver operating characteristic(ROC)curve.Results The ultrasound gray scale ratio of benign and malignant thyroid nodules to surrounding normal tissues were(0.78±0.28)and(0.49±0.21),respectively,and the difference was statistically significant(P<0.05).When the ultrasound gray scale ratio was 0.605,the sensitivity,specificity and area under the curve in the differential diagnosis of benign and malignant thyroid nodules were 79.1%,75.1%and 0.853,respectively.Conclusion The ultrasound gray scale ratio has a certain value in the differential diagnosis of benign and malignant thyroid nodules.