双链RNA结合蛋白ILF3在神经系统疾病中的研究进展

Research Advances of Double-stranded RNA Binding Protein ILF3 in Neurological Diseases

白介素增强结合因子3(ILF3)通过双链RNA结合序(dsRBM)及其他结构域与RNA进行结合,参与了RNA转录、翻译、编辑和运输等相关过程,基是重要的RNA调控蛋白。在神经系统相关领域的研究中发现,ILF3与胚胎神经系统的发生、正常结构和功能的维持存在密切联系,同时与众多神经系统疾病如退行性病变、缺血缺氧损伤、病毒感染、肿瘤或精神障碍等也具有相关性。该文着重回顾了ILF3蛋白在神经领域中的研究进展,希望对相关神经系统疾病的干预研究提供思路。

Interleukin-enhanced binding factor 3(ILF3),which is an important RNA regulatory protein,binds to RNA through double-stranded RNA binding motifs(dsRBM)and other domains.It participates in the RNA transcription,translation,editing,transportation and other processes.ILF3 is tightly associated with the occurrence of the embryonic nervous system and the normal structure and function.Moreover,it is also related to multiple neurological diseases,such as neurodegeneration,ischemic hypoxia injury,viral infection,nervous system tumor and mental disorder.This review focuses on the researches of ILF3 protein in the field of neuroscience and is hoped to provide insight into the intervention of neurological diseases.