剪切波弹性成像联合MRI对干燥综合征涎腺病变的诊断价值

Value of shear wave elastography combined with MRI in the diagnosis of salivary gland lesions in Sj?gren’s syndrome

目的探讨剪切波弹性成像联合MRI对干燥综合征涎腺病变的诊断价值。方法选取我院收治的63例健康体检者(对照组)和110例干燥综合征涎腺病变患者(观察组),其中观察组患者根据病情严重程度进一步分为轻度组69例和重度组41例,各组均行剪切波弹性成像和MRI检查,比较双侧颌下腺及腮腺杨氏模量值、T1WI、T2WI、脂肪信号分级、腮腺导管扩张分级。绘制受试者工作特征(ROC)曲线分析各指标单独及联合应用诊断干燥综合征涎腺病变的价值。结果重度组双侧颌下腺杨氏模量值、腮腺杨氏模量值、T1WI、T2WI、脂肪信号分级、腮腺导管扩张分级均高于轻度组和对照组,差异均有统计学意义(均P<0.05);轻度组上述指标均高于对照组,差异均有统计学意义(均P<0.05)。ROC曲线分析显示,各指标联合应用诊断干燥综合征涎腺病变的敏感性100%,特异性89.9%,曲线下面积(AUC)0.971。联合应用的AUC与双侧颌下腺杨氏模量值、双侧腮腺杨氏模量值、T1WI、T2WI、脂肪信号分级、腮腺导管扩张分级单独应用的AUC比较差异均有统计学意义(Z=3.671、4.391、4.603、4.353、5.709、5.128、4.985、3.514,均P<0.001)。结论剪切波弹性成像联合MRI对干燥综合征涎腺病变有一定诊断价值。

Objective To explore the value of shear wave elastography(SWE)combined with MRI in the diagnosis of salivary gland lesions in Sj?gren’s syndrome.Methods A total of 63 healthy subjects(control group)and 110 patients with Sj?gren’s syndrome salivary gland lesions(observation group)were collected.The observation group was further divided into mild group(n=69)and severe group(n=41)according to the severity of the disease.All above groups were examined by SWE and MRI.The Young’s modulus of bilateral submandibular and parotid glands,T1 WI,T2 WI,parotid duct dilatation grade,fat signal grade among groups were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the value of above indexes application alone and combined in the diagnosis of salivary gland lesions in Sj?gren’s syndrome.Results The Young’s modulus of bilateral submandibular and parotid glands,T1 WI,T2 WI,fat signal grade and parotid duct expansion grade in the severe group were higher than those in the mild group and control group(all P<0.05).The above indexes in the mild group were higher than those in the control group(all P<0.05).ROC curve analysis showed that the sensitivity,specificity and the area under the curve(AUC)of above indexes application combined were 100%,89.9%and 0.971,respectively.There were significant differences of AUC between combined application and bilateral submandibular,bilateral parotid,T1 WI,T2 WI,fat signal grade,parotid duct expansion grade(Z=3.671,4.391,4.603,4.353,5.709,5.128,4.985,3.514,all P<0.001).Conclusion SWE combined with MRI has a certain value in the diagnosis of salivary gland lesions in Sj?gren’s syndrome.