吉林省近足月儿病理性黄疸与围生因素的相关性分析

Correlation analysis of pathological jaundice and perinatal factors in near-term infants in Jilin Province

目的探讨吉林省近足月儿病理性黄疸与围生因素的相关性。方法选择2019年7月—2020年7月由吉林省妇幼保健院牵头的吉林省地区内9所医院出生的部分近足月儿(胎龄≥35周且出生体质量≥2000 g)为研究对象,定期监测生后5 d的经皮胆红素(TCB)水平,记录其相关围生因素,采用χ^(2)检验及二元Logistic回归法分析,找出近足月儿病理性黄疸与围生因素的相关性。结果此研究共纳入3806例近足月儿,采用χ^(2)检验单因素分析得出,病理性黄疸与民族、胎龄、胎儿窘迫、胎膜早破、分娩方式、妊娠期糖尿病、喂养方式及体质量下降值具有相关性,差异均有统计学意义(均P<0.05),与性别、出生体质量、头颅血肿及妊娠期高血压疾病没有相关性,差异均无统计学意义(均P>0.05)。采用二元Logistic回归多因素分析得出,胎龄(35~37周)、母乳喂养、体质量下降值≥100 g是影响病理性黄疸的独立高危因素,差异均有统计学意义(均P<0.05)。结论近足月儿病理性黄疸与民族、胎龄、胎儿窘迫、胎膜早破、分娩方式、妊娠期糖尿病、喂养方式及体质量下降值具有相关性,且胎龄(35~37周)、母乳喂养及体质量下降值≥100 g是病理性黄疸的独立高危因素,值得临床高度重视。

Objective To investigate the correlation of pathological jaundice in near-term children and perinatal factors in Jilin Province.Methods Nine hospitals in Jilin Province led by Jilin Maternal and Child Health Hospital from July 2019 to July 2020,Some near-term children(35 weeks of gestational age and birth weight of 2000 grams)were the study subjects,The TCB values were regularly monitored for the first 5 days of life,Record its related perinatal factors,Chi-square test and logistic regression analysis,Find out the correlation between pathological near-term jaundice and perinatal factors.Results This study included 3806 cases of near term,using chi-square test univariate analysis,pathological jaundice and gestational age,delivery,feeding,ethnic,weight loss,premature rupture,intrauterine distress,gestational diabetes,difference(all P<0.05),and gender,birth weight,head hematoma,pregnancy hypertension,no difference(all P>0.05).logistic regression multivariate analysis showed that gestational age was between35 weeks and 37 weeks,a weight loss value of 100 g,and breastfeeding were independent high risk factors for pathological jaundice,which were statistically significant(all P<0.05).Conclusion Near-term pathological jaundice is associated with gestational age,delivery mode,feeding method,nationality,weight loss value,premature fetal membrane rupture,intrauterine distress,gestational diabetes.gestational age was between 35 weeks and 37 weeks,weight loss value of 100 g,and breastfeeding are the independent influencing factors of pathological jaundice.These deserves great clinical attention.