短期使用达格列净对射血分数下降型心力衰竭合并2型糖尿病患者临床疗效的影响

Effect of Short-term Use of Gliclazin on the Treatment of Heart Failure with Ejection Fraction and Type 2 Diabetes Mellitus

目的探讨短期使用达格列净对射血分数下降型心力衰竭(HFrEF)合并2型糖尿病患者N末端B型利钠肽前体(NT-proBNP)、超敏肌钙蛋白T(hs-cTnT)及6 min步行试验(6MWT)的影响。方法选取2020年1月至2021年1月广东医科大学附属医院心血管内科住院治疗HFrEF合并2型糖尿病患者62例作为研究对象,按治疗方法不同分为对照组25例与观察组37例。对照组使用基础降糖方案治疗,观察组使用基础降糖方案联合达格列净治疗,治疗时间2周,比较两者临床疗效、NT-proBNP、hs-cTnT、6MWT等。结果观察组治疗有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后两组患者血清NT-proBNP、hs-cTnT水平降低,6MWT增加,且观察组NT-proBNP、hs-cTnT、6MWT水平优于对照组,差异有统计学意义(P<0.05);两组治疗过程中未见明显不良反应。结论达格列净治疗HFrEF合并2型糖尿病患者短期疗效显著,且在治疗过程中未见明显不良反应,具有良好的安全性。

Objective To explore the short-term effects of the treatment of Da Gli on the heart failure and type 2 diabetes mellitus with NT-proBNP,cardiac troponin T and six minute walk test.Methods A total of 62 patients with preserved heart failure and type 2 diabetes mellitus who were hospitalized in the Department of Cardiology of Guangdong Medical University from January 2020 to January 2021 were selected as the research subjects.All the patients were divided into 25 cases in the control group and 37 cases in the treatment group according to different treatment methods..The control group was treated with the basal hypoglycemic regimen.The treatment group was treated with basic treatment of heart failure and hypoglycemic regimen combined with dagliejing for 2 weeks.The clinical efficacy,NT proBNP,troponin T and six minute walking test distance were compared.Results The effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05);after treatment,the serum NT-proBNP,hs-cTnT levels of the two groups of patients decreased,and 6 MWT increased,and the NT-proBNP,hs-cTnT,6 MWT levels of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05);there were no obvious adverse reactions during the treatment of the two groups.Conclusion Dapagliflozin has a significant short-term effect in the treatment of patients with HFrEF and type 2 diabetes,and there are no obvious adverse reactions during the treatment process,and it has good safety.