基于SEER数据库乳腺浸润性筛状癌临床病理特征及预后因素分析

Analysis of clinicopathologic features and prognosis of invasive cribriform carcinoma of breast based on SEER database

目的探讨乳腺浸润性筛状癌的临床病理特征、预后及相关影响因素。方法选择2010—2016年美国国立癌症研究监测、流行病学和最终结局(SEER)数据库中诊断为乳腺浸润性筛状癌的388例病例资料,回顾性分析其临床病理特征与生存情况,及其预后影响因素。结果在388例病人中,287例(74.0%)为T1期,321例(82.7%)为N0期,374例(96.4%)接受手术治疗,204例(52.6%)接受放疗,85例(21.9%)接受化疗。病人3、5年总体生存率分别为94.4%、88.4%。单因素分析显示,年龄、婚姻状态、T分期、M分期、手术、放疗是影响乳腺浸润性筛状癌病人生存预后的相关因素(P<0.05)。多因素分析显示,年龄、T分期、M分期、放疗是影响乳腺浸润性筛状癌病人预后的独立危险因素(P<0.05)。结论影响浸润性筛状癌病人预后的独立危险因素包括年龄、T分期、M分期。放疗对浸润性筛状癌病人的生存率是否有益仍需对浸润性筛状癌进一步深入研究。

Objective invasive cribriform carcinoma of breast.MethodsThe data of 388 patients with invasive cribriform carcinoma of breast were downloaded from Surveillance,Epidemiology,and End Results(SEER)database.The clinicopathologic characteristics,the survival status and the influential factors for prognosis of the patients were retrospectively analyzed.Results T1 tumors,321 cases(82.7%)were stage N0 tumors,374 cases(96.4%)received surgery,204 cases(52.6%)received radiotherapy,and 85 cases(21.9%)received chemotherapy.The overall 3-and 5-year survival rates were 94.4%and88.4%,respectively.Univariate analysis showed that age,marital status,T stage,M stage,surgery and radiotherapy were significantly associated with the prognosis of the patients with invasive cribriform carcinoma of breast(P<0.05).Multivariate analysis revealed that age,T stage,M stage and radiotherapy were independent risk factors for prognosis of the patients with invasive cribriform carcinoma of breast(P<0.05).Conclusion prognosis of the patients with invasive ethmoid carcinoma of breast include age,T stage and M stage.Whether radiotherapy is beneficial to the survival of patients with invasive ethmoid carcinoma is still necessary to be further studied.