糖尿病肾病标志物的研究进展

Research Progress on Markers of Diabetic Nephropathy

糖尿病肾病(Diabetic Kidney Disease,DKD)是糖尿病的常见并发症,并可最终导致终末期肾脏病(End-Stage Renal Disease,ESRD),目前DKD的诊断和分期主要依靠尿微量白蛋白和估算的肾小球滤过率(estimated Glomerular Filtration Rate eGFR),越来越多的研究提示其敏感度和特异度不足。本文将依据既往研究的标志物进行分类并加以总结,提供对糖尿病肾病标志物研究新的思路,以期运用于临床。

Diabetic nephropathy disease(DKD)is a common complication of diabetes and can lead to end-stage Renal Disease(ESRD).At present,the diagnosis and staging of DKD are mainly based on urinary microalbumin and estimated glomerular filtration rate(eGFR).But more and more studies indicated that its sensitivity and specificity were insufficient.In this papei;we will classify and summarize the bio markers from previous studies,and provide new ideas for the study of diabetic nephropathy biomarkers,with a view to their clinical application.