丁苯酞联合银杏叶提取物片治疗脑梗死恢复期患者疗效观察

Observation on curative effect of butylphthalide combined with ginkgo biloba extract tablets in the treatment of convalescent cerebral infarction patients

目的探讨丁苯酞联合银杏叶提取物片治疗脑梗死恢复期患者的临床疗效。方法将139例脑梗死恢复期患者按照随机数字表法分为研究组70例,对照组69例。两组均给予丁苯酞软胶囊治疗,研究组在此基础上联合银杏叶提取物片治疗。比较两组临床疗效,治疗前后采用美国国立卫生研究院卒中量表评定两组神经功能,采用简易智力状态检查量表评定两组认知功能,采用脑卒中专用生活质量量表评定两组生活质量,比较两组不良反应发生率。结果研究组治疗总有效率显著高于对照组(P<0.05)。治疗后两组美国国立卫生研究院卒中量表评分较治疗前显著降低(P<0.01),简易智力状态检查量表评分及脑卒中专用生活质量量表各维度评分较治疗前显著升高(P<0.01),研究组较对照组变化更显著(P<0.01)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论丁苯酞联合银杏叶提取物片治疗脑梗死恢复期效果显著,能促进患者神经功能恢复,改善患者认知功能及生活质量,安全性高。

Objective To explore the curative effect of butylphthalide combined with ginkgo biloba extract tablets in the treatment of convalescent cerebral infarction patients.Methods A total of 139 patients with cerebral infarction in convalescent period were divided into study group(n=70) and control group(n=69)according to random number table method.Both groups were treated with butylphthalide soft capsule,and the study group was treated with ginkgo biloba extract tablets.The clinical effects of the two groups were compared.Before and after treatment,the National Institutes of Health stroke scale(NIHSS) was used to evaluate the neurological function of the two groups,mini-mental state examination(MMSE) was used to evaluate the cognitive function of the two groups,stroke specific quality of life scale(SS-QOL) was used to evaluate the quality of life of the two groups,and the incidence of adverse reactions was compared between the two groups.Results The total effective rate of the study group was significantly higher than that of the control group(P<0.05).After treatment,the NIHSS scores of the two groups were significantly lower than those before treatment(P<0.01),and the MMSE scores and SS-QOL scores were significantly higher than those before treatment(P<0.01).The study group changed more significantly than the control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Butylphthalide combined with ginkgo biloba extract tablets is effective in the treatment of convalescent cerebral infarction patients,which can promote the recovery of neurological function,improve the cognitive function and quality of life of patients,and has good safety.