摘要
In a recent study published in Nature,Witkowski et al.reported that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGF-β)secretion counteracts interferon-alpha(IFN-α)-induced activation of NK cells by decreasing expression of transcription factor T-bet.Consequently,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells.
基金
Research in the Förster lab gets supported by the German Center for Infection Research TTU 01.938(grant no 80018019238)
by the German Center for Lung Research(grant 82DZL002B1)
by Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Excellence Strategy EXC 2155“RESIST”(Project ID39087428)
SFB 900/3(Project B1,158989968)
FO334/7-1(all to R.F.).
