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A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants

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摘要 Dear Editor,The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is a great threat to global public health.Although several vaccines and therapeutic antibodies have been authorized for emergency use,several studies have reported that they show weakened protective effects against SARS-CoV-2 variants,including Alpha,Beta,Gamma,and currently dominant Delta and Lambda.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2022年第2期362-365,共4页 信号转导与靶向治疗(英文)
基金 This work was supported by the Ministry of Science and Technology of the People’s Republic of China(2021YFC0863300) the National Key Research and Development Program of China(2020YFA0509202) the Strategic Priority Research Program of CAS(XDB29040203).
关键词 ACE2 protective ACUTE
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