摘要
The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporated into the alkene structure(CXL 118,CXL121,and CXL122)is described in this report.The results indicated that these compounds are selectively located in lysosomes and exhibit effective antitumour activity.Notably,these compounds can directly serve as both reporting and imaging agents in vitro and in vivo without the need to add other fluorescent tagging agents.
基金
supported by Science and Technology Department of Sichuan Province(Nos.2020YJ0237,2018SZ0030,2019YFH0119)
National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(Z20191006)
the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYJC18025 and ZYJC18003).
